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Packet 10: Bonus 2

An inherited mutation in this protein is the primary cause for Li-Fraumeni syndrome. For 10 points each:
[10m] Name this protein that is regulated by the oncoprotein MDM2. This protein’s nickname, the “Guardian of the Genome”, was coined by David Lane.
ANSWER: p53 [or TP53; or tumor protein p53]
[10e] p53 is a protein that suppresses the growth of these structures. These abnormal masses of cells can be classified as benign or malignant depending on whether they are cancerous.
ANSWER: tumors [or cancer tumors; accept tumor microenvironment; prompt on neoplasms]
[10h] In order for p53 to lose its tumor-suppressing function, both alleles of the TP53 gene must be inactivated, making TP53 a gene partially named for this scientist. This American geneticist’s research on cancer in the retina led him to postulate the two-hit hypothesis.
ANSWER: Alfred G. Knudson [or Alfred George Knudson Jr; accept Knudson hypothesis]
<Science - Biology, Spencer Manning> | VAULT II Packet 10

HeardPPBE %M %H %
3819.21100%66%26%

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Conversion

TeamOpponentPart 1Part 2Part 3TotalParts
Birmingham BBath010010E
OxfordSouthperial010010E
SouthamptonCambridge10101030MEH
WarperialBirmingham A1010020ME

Summary

TournamentEditionMatchHeardPPBE %M %H %
VAULT II at Georgia Tech2026-01-24✓626.67100%100%67%
VAULT II at Eden Prairie HS2026-03-13✓316.67100%67%0%
VAULT II at McGill2026-03-13✓412.50100%25%0%
VAULT II at UCSB2026-03-13✓520.00100%80%20%
VAULT II Northern UK2026-04-24✓310.00100%0%0%
VAULT II Southern UK2026-04-24✓417.50100%50%25%
VAULT II at Harvard2026-04-30✓420.00100%100%0%
VAULT II at MINT2026-06-19✓110.00100%0%0%
VAULT II Stanford Online2026-07-17✓822.50100%75%50%