Packet 10: Bonus 2
An inherited mutation in this protein is the primary cause for Li-Fraumeni syndrome. For 10 points each:
[10m] Name this protein that is regulated by the oncoprotein MDM2. This protein’s nickname, the “Guardian of the Genome”, was coined by David Lane.
ANSWER: p53 [or TP53; or tumor protein p53]
[10e] p53 is a protein that suppresses the growth of these structures. These abnormal masses of cells can be classified as benign or malignant depending on whether they are cancerous.
ANSWER: tumors [or cancer tumors; accept tumor microenvironment; prompt on neoplasms]
[10h] In order for p53 to lose its tumor-suppressing function, both alleles of the TP53 gene must be inactivated, making TP53 a gene partially named for this scientist. This American geneticist’s research on cancer in the retina led him to postulate the two-hit hypothesis.
ANSWER: Alfred G. Knudson [or Alfred George Knudson Jr; accept Knudson hypothesis]
<Science - Biology, Spencer Manning> | VAULT II Packet 10
| Heard | PPB | E % | M % | H % |
|---|---|---|---|---|
| 38 | 19.21 | 100% | 66% | 26% |
Conversion
| Team | Opponent | Part 1 | Part 2 | Part 3 | Total | Parts |
|---|---|---|---|---|---|---|
| Always Set the Kurve | Big Brown Ballers | 0 | 10 | 0 | 10 | E |
| Leif Eriksen's Striking Appearance | Taman's Nepo Babies | 10 | 10 | 0 | 20 | ME |
| Midnight Bus to Vista | whatever | 10 | 10 | 0 | 20 | ME |
| Prat Pack | Heauton Timorumenos | 10 | 10 | 10 | 30 | MEH |
| With Less Than 2 Years of Combined Quizbowl Experience | Albanian Rift in the Sky | 10 | 10 | 0 | 20 | ME |
Summary
| Tournament | Edition | Match | Heard | PPB | E % | M % | H % |
|---|---|---|---|---|---|---|---|
| VAULT II at Georgia Tech | 2026-01-24 | ✓ | 6 | 26.67 | 100% | 100% | 67% |
| VAULT II at Eden Prairie HS | 2026-03-13 | ✓ | 3 | 16.67 | 100% | 67% | 0% |
| VAULT II at McGill | 2026-03-13 | ✓ | 4 | 12.50 | 100% | 25% | 0% |
| VAULT II at UCSB | 2026-03-13 | ✓ | 5 | 20.00 | 100% | 80% | 20% |
| VAULT II Northern UK | 2026-04-24 | ✓ | 3 | 10.00 | 100% | 0% | 0% |
| VAULT II Southern UK | 2026-04-24 | ✓ | 4 | 17.50 | 100% | 50% | 25% |
| VAULT II at Harvard | 2026-04-30 | ✓ | 4 | 20.00 | 100% | 100% | 0% |
| VAULT II at MINT | 2026-06-19 | ✓ | 1 | 10.00 | 100% | 0% | 0% |
| VAULT II Stanford Online | 2026-07-17 | ✓ | 8 | 22.50 | 100% | 75% | 50% |